Help please? what is the chance of a severe skin reaction to tylenol (acetaminophen)?

Reaction to tylenol (acetaminophen): Allergic reactions can occur with any medication, even those that are over the counter like tylenol (acetaminophen). While I am not sure what the exact percentages are for a medication like tylenol (acetaminophen), it is possible to have an skin outbreak with it. I would look at when you took the medication and when the reaction happened. Also was this the first time you took the medication? Hope this helps.