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How does strattera (atomoxetine) help for adhd if it is a norepinephrine reuptake inhibitor , without affecting dopamine ?

3 doctors weighed in across 2 answers

Don't know!: If straterra is a norepinephrine reuptake inhibitor it increases the norepinephrine level in the brain. Methylphenidate stimulants, used in adhd work that way. In my opinion, straterra which was initially unsuccessfully marketed as an antidepressant is not a first line choice for adhd.

Answered 2/12/2014

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Strattera (atomoxetine) blocks : Reuptake of norepinephrine but rat studies show that it also raises levels of Dopamine in the prefrontal cortex 3x without raising levels in the nucleus accumbens that controls addiction and where the other stimulant drugs also act. Dr. Stephen stahl calls some of the cells in the prefrontal cortex promiscuous because they contain both norepinephrine and dopamine. There is more to be learned.

Answered 4/8/2016

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