Please explain if it is safe to take hydrocodone 7.5 with .25 (2x a day) xanax (alprazolam) (generic)?

It depends.: Opiate pain meds and benzodiazepines are both sedatives. They can cause drowsiness, incoordination and dizziness due to low blood pressure. Although you may be taking the recommended or average doses for both meds, you should check to see how they affect you and use caution when driving or operating other machinery. Also do not drink alcohol while you are taking them.