Can you tell me about drug interactions of oxycodone/hydrocodone?

Very few: In terms of increasing or reducing the levels/ effectiveness of other drugs, these opioids have few if any drug interactions. However, for any other drug which can be a central nervous system depressant, like alcohol, sedatives, tranquillizers, antihistamines and many other drugs, the combination can cause increased potential for respiratory depression, fainting, sedation, accidents, falling.