How can parkinson's disease affect the nervous system?

Neurotransmitters: Parkinson's disease is a multi-neurotransmitter deficiency syndrome in part, with the classical effect on dopamine. This accounts for the tremors and gait instability. At same time deposition of Lewy bodies within the cell body cause cellular death. In many patients, a Parkinsonian dementia arises, which is different from Alzheimer's.