How does parkinson's disease affect the nervous system?

Complex disorder: Predominantly a disease of low levels of neurotransmitters in the brain involving pigmented nuclei. Main culprit is declining dopamine level in basal ganglia, which can be replaced in part by L-DOPA, but affects other parts of brain, especially dorsal vagal nucleus, locus ceruleus, and can damage nerve cells by presence of Lewy bodies. Recommend more at aan.com or Mayo Clinic site.

Neurotransmitters: Parkinson's disease is a multi-neurotransmitter deficiency syndrome in part, with the classical effect on dopamine. This accounts for the tremors and gait instability. At same time deposition of Lewy bodies within the cell body cause cellular death. In many patients, a Parkinsonian dementia arises, which is different from Alzheimer's.