A 21-year-old member asked:
how does phosphate trigger pseudomonas aeruginosa infections?
2 doctor answers
Dr. Michael Depietro answered
34 years experience Pulmonary Critical Care
By changing genes: This is not completely understood, but there is experimental evidence from animal experiments and such, that the pseudomonas grown in a low phosphate environment will respond on changes in what genes the germ activates. These changes lead the bacteria to make chemicals that increase its ability to grow and cause damage. In patients with low phosphate levels this may mean > risk of infection.
Answered on Jul 5, 2012
Dr. Tony Ho answered
13 years experience Infectious Disease
Inducible virulence: Pseudomonas demonstrates increased virulence when it is grown in an environment that starves it of phosphate; it affects expression of virulence genes when the organism detects low levels of phosphate.
Answered on Feb 10, 2014
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