A 21-year-old member asked:
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how does phosphate trigger pseudomonas aeruginosa infections?

2 doctor answers
Dr. Michael Depietro
34 years experience Pulmonary Critical Care
By changing genes: This is not completely understood, but there is experimental evidence from animal experiments and such, that the pseudomonas grown in a low phosphate environment will respond on changes in what genes the germ activates. These changes lead the bacteria to make chemicals that increase its ability to grow and cause damage. In patients with low phosphate levels this may mean > risk of infection.
Answered on Jul 5, 2012
Dr. Tony Ho
Dr. Tony Ho answered
13 years experience Infectious Disease
Inducible virulence: Pseudomonas demonstrates increased virulence when it is grown in an environment that starves it of phosphate; it affects expression of virulence genes when the organism detects low levels of phosphate.
Answered on Feb 10, 2014
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Related questions:

A 22-year-old member asked:
Dr. Scott Bolhack
34 years experience Wound care
Probiotics Use: There is no evidence that probiotics can prevent a pseudomonas infection.
A 21-year-old member asked:
Dr. Pavel Conovalciuc
22 years experience Family Medicine
Yes and no: Pseudomonas can be transmitted differently - contact exposure, airborne. Also, it may live on some of us without causing any disease, but when local i ... Read More
A 21-year-old member asked:
Dr. Sahba Ferdowsi
17 years experience General Practice
Not likely: Although there are some studies that show that honey can kills some bacteria. I would recommend seeing your doctor for antibiotics.
A 21-year-old member asked:
Dr. Michael Depietro
34 years experience Pulmonary Critical Care
Not really: Pseudomonas is a very dangerous bacteria that infects those who are chronically or critically ill . ( such patients with cystic fibrosis or in the i ... Read More

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