Can mitral regurgitation start at anytime if mitral valve prolapse?

Yes: As we age and the heart changes, mitral prolapse may progress and lead to regurgitation. Mild regurgitation is harmless and nearly ubiquitous in the general population, even without mvp. Serious mvp which is relatively rare can be associated with sudden rupture of a chordal attachment and result in sudden, severe regurgitation which can happen anytime, is serious, and needs treatment.

Yes: When the mitral valve prolapse starts leaking blood back from the left ventricle to the left atrium.