Please tell me if it is safe to mix morphine sulfate with vicodin?

Mixing narcotics : Yes, provided the drugs are prescribed & monitored by your physician. Vicodin (hydrocodone/acetaminophen) is a short acting oral narcotic analgesic to be taken as needed for moderate-severe pain. Oral Morphine may be immediate release or sustained release (long acting). Most commonly a sustained release Morphine will be prescribed with short acting hydrocodone for "rescue" or "breakthrough pain".

No,: It is not, you would need to be monitored professionally or it could be lethal