Same as second-time: and subsequent, just more powerful. Heroin is not unique, and other opioids that are well-absorbed and rapidly pass the blood/brain barrier produce pretty much identical effects. There is a tremendous euphoria or "rush" followed by sedation. If the dose is too high, esp in a opioid-naive individual, oversedation with respiratory depression can occur. There is a strong desire to repeat experience.
Answered 5/11/2014
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