Depends on opiate: Most meds are out of your system after 5 half-lives. Methodone has a 24 hour half life, so you may block any residual up to 5 days later. Most others are shorter acting. As a rule of thumb, if you are not having withdrawal symptoms and are several days past last use, i would say you are safe to start naltrexone.
Answered 5/8/2016
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Naltrexone: “Prevention of relapse after opioid detoxification; to be used only after patient has been opioid-free for 7-10 days and after negative naloxone challenge (no symptom withdrawal after naloxone administration)” REF: https://reference.medscape.com/drug/vivitrol-revia-naltrexone-343333
Answered 11/17/2018
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