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A 49-year-old male asked:

Discussing switching from cymbalta (duloxetine) to zoloft for ocd---afraid of weight gain on zoloft---what is likelihood of zoloft weight gain...active..watch diet?

2 doctor answers3 doctors weighed in
Dr. Donald Jacobson
A Verified Doctoranswered
A US doctor answeredLearn more
Zoloft (sertraline) weight gain: Weight gain on zoloft (sertraline) is actually quite rare. When it does occur it tends to occur late into use, say six months to a year into use but only in approximately one or 2% of people. It is generally considered weight neutral. Of course watching weight, exercising, and watching your diet are all extremely important. Best wishes for a happy holiday season.
Dr. Heidi Fowler
Psychiatry 25 years experience
Agree- quite weight: neutral. According to a study published in the Journal of Clinical Psychiatry the average weight gain was 0.1% after > 1 year on zoloft (sertraline). 4.5% people treated with zoloft (sertraline) had a significant weight gain in one study. Weight gain is more likely if the person is taking zoloft (sertraline) for 6 months or longer. There are some people who experience increased carbohydrate craving on zoloft (sertraline). However, mechanism for wei
Dr. Heidi Fowler
Psychiatry 25 years experience
Provided original answer
Sep 30, 2014

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Last updated Sep 29, 2016

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