There are some: People who find that after taking zoloft (sertraline) for a long period that it may lose some effectiveness. However, most folks who respond well to it can continue to use it long term without efficacy problems.
Answered 9/26/2018
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Possible: Young male healthy on a low dose of zoloft (sertraline) may need a higher level to reach effective state.
Answered 11/26/2013
4.7k views
Very low: You don't develop tolerance to ssri's like zoloft (sertraline). That is one reason it works so well.
Answered 9/26/2018
4.7k views
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