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A 25-year-old male asked:

Zoloft (sertraline) works quite well for me (0 side effects). how likely is it for someone like me to develop a tolerance to zoloft (sertraline) if i keep using it for years?

3 doctor answers3 doctors weighed in
Dr. Heidi Fowler
Psychiatry 27 years experience
There are some: People who find that after taking zoloft (sertraline) for a long period that it may lose some effectiveness. However, most folks who respond well to it can continue to use it long term without efficacy problems.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. John Hanna
Family Medicine 37 years experience
Possible: Young male healthy on a low dose of zoloft (sertraline) may need a higher level to reach effective state.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Daniel Steffy
Family Medicine 16 years experience
Very low: You don't develop tolerance to ssri's like zoloft (sertraline). That is one reason it works so well.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Sep 26, 2018

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