Yes, it is: Chronic urticaria is sometimes very hard to treat. First line, high dose antihistamines. After higher than usual doses of these there is a plethora of medications added to those, starting with h2 blockers and montelukast. If that combination is ineffective, hydroxy-chloroquine, dapsone, cyclosporine, tacrolimus, ivig and possibly xolair. Can be tried. See an allergist/immunologist.
Answered 2/8/2017
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