How do you diagnose mylofibrosis in early stages? my grandmother died of it, i am always exhausted, tired sore muscles, dark skin around eyes nasally

Bone marrow biopsy: A bone marrow biopsy is the best way to diagnose myelofibrosis. Signs that one may have this disease include anemia, an enlarged spleen, and odd looking red blood cells called teardrop cells (they look just like teardrops in shape). Myelofibrosis is generally not an inherited disease. An evaluation by a doctor can help figure out why one is always exhausted, etc.