Do all sickle cell patients have the exact same mutation?

Sickle cell anemia: There are many different types of sickle cell anemia. How bad someone's disease is depends on which part of africa their family originally came from and whether the sickle cell gene is combined with any other hemoglobin mutations. For instance, sickle cell + hemoglobin c or sickle cell + thalassemia often gives the patient milder disease than plain sickle cell anemia.