Why is it so hard to come off of prednisone after long term use?

adrenal suppression: Oral Prednisone increases the vascular level of prednisone, which causes the biofeedback system of the human body to shut the adrenal output of steroid down. If you stop the oral steroids abruptly, you will suffer from low steroid level, called addisonian crisis. So, to get off oral steroids, you must be weaned slowly from that drug. Good luck.