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A member asked:
Does glycyrrhizic acid (in liquorice root) have glucocorticoid effects? if so, has it ever been studied for use in treating lo-cah? study links?
A doctor has provided 1 answer
No: Glycyrrhizinic acid inhibits an enzyme in the kidney (11β-hydroxysteroid dehydrogenase). This enzyme inactivates cortisol in the kidney. Inhibition of this enzyme leads to decreased inactivation of cortisol and thus to increased cortisol levels. Not expected to work in cah since this is characterized by an inabilty to make cortisol.
Answered 9/29/2016
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