Are zyprexa and geodon (ziprasidone) similar? can they be switched out from one another?

Sort of: They both are atypical antipsychotics. However, they block different sets of receptors and they have rather different side effect profiles. There would need to a cautious exploration likely required to find an effective equivalent dose and this search could prove anywhere from challenging to impossible depending on the severity of the symptoms and the treatment resistance of the condition.