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A member asked:
Is it true that opioids in higher doses have antiemetic effects vs lower doses because it depresses the vomiting center?
A doctor has provided 1 answer
yes: High doses of some opioids may decrease n/v by interacting with receptors in the vomiting center, rather than the ctz (chemoreceptor trigger zone ).The relationship between opioids use and n/v is complex. The vomiting center in the medulla oblongata, receives input from 4 areas; chemoreceptor trigger zone gi tract vestibular apparatus -temporal lobe cerebral cortex.
Answered 4/17/2014
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