Is schizophrenia worse with zoloft (sertraline)?

in general: No, as a general rule ssri would not worsen symptoms of schizophrenia. In fact, many patients with this condition have depression, and in those cases the use of antidepressants like zoloft (sertraline) is the norm. However every case is different so the best way to know this for a particular case, is to consult the prescribing dr. Best wishes.