Depends: Both drugs are effective in the treatment of osteoporosis involving the hip. Prolia is likely to work better than reclast, (zoledronic acid) though there are no head to head studies comparing the two. Prolia is typically used in people who have had a previous fracture (spine, wrist), or have very severe osteoporosis. Both are well tolerated with few side effects. Prolia is given twice yearly, Reclast (zoledronic acid) once yearly.
Answered 2/23/2020
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