Prozac (fluoxetine) restlessness: Yes. This is a side effect of Prozac (fluoxetine) where there is either a worsening of restless leg syndrome toward evening, or all day restlessness called an akathisia. They should eventually improve , but if they don't , you should call your dr so it can be treated before the next appointment. Best wishes to you. If you have restless legs, the antihistamine can worsen that as well.
Answered 6/30/2014
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