Question 1

what does it mean when large and giant platelets are found in blood smear, rbc morphology and poikilocytosis?

what causes large and giant platelets to show up?

Accepted Answer

Can be normal: Healthy persons can have normal juvenile large platelets. The more juvenile, the more larger platelets there are. EDTA in testing of MCV can cause clumping of platelets which may make them appear larger than normal. However, abnormally large platelets may be seen in Glanzman thrombasthenia, primary myelofibrosis or in myeloproliferative disorders. Discuss findings with your DR.

Question 2

havent been feeling well at all. blood smear showed large/giant platelets present/rbc morphology present/poikilocytosis 2+ /wbc 11.1 rbc 5.41/keystones 15, trace blood urine, bp elevation now on bp meds. what can cause those results(blood smear)?

Accepted Answer

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, the data you provided is not diagnostic of anything.   Wish you good health!

Question 3

what does platelet anisocytosis mean on blood smear? platelet count is 454k. (10 days ago it was 482k)

Accepted Answer

Both are normal.: Most labs use as a normal range for platelets to be 150, 000 to 450, 000.  The slight increase you wrote of are not concerning.  Anisocytosis refers to change in size---not all the same size platelets.  Large platelets can be associated with many things, including bone marrow replacement with younger platelets.  Smaller platelets can be associated with different genetic conditions or may be normal.

Question 4

what does the presence of giant platelets on blood work mean ?

Accepted Answer

Large platelets: Are "young" platelets, ie recently released from the marrow. Likely no significance.

Question 5

abnormal blood smear..i have (h) wbc (l) rbc and (h) platelets and tear drop cells and helmet cells....what is this?

Accepted Answer

Blood smear?: That gives information about the number and shape of blood cells. Tear drop may indicate myelofibrosis, severe iron deficiency, thalassemia major. Schistocyte or helmet cell seen in hemolitic anemia like hemolitic uremic syndrome and artificial heart valves and some other microangiopathic diseases. See your physician for clinical correlation of the results. Shapes are not diagnostic of a disease.

Question 6

does normal adamsts13 and normal platelet count rule out ttp from plavix ? is a blood smear , coombs and ldh required ?

Accepted Answer

: Normal platelet count rules out Thrombotic Thrombocytopenic Purpura. Thrombocytopenic means low platelet count. Take care.

Question 7

could a cut on my foot raise my platelets? count of 700, wbc 13, no other symptoms. found on routine cbc. blood smear clean.

Accepted Answer

Not the cut: Follow it. If you are iron deficient, find the cause and get treated. You may have a check to see if a particular mutation is driving it. This is serious but probably not catastrophic.

Question 8

what does it mean to have ovalocytes in a blood smear?

Accepted Answer

Depends: If hemoglobin level is normal, it does not mean anything. Some hemoglobin variants produce oval rather than perfectly round red cells and then it depends on the type of hemoglobin variant. A few ovalocytes are of no consequence.

Question 9

does anyone know what it means to have ovalocytes in a blood smear?

Accepted Answer

Usually Harmless: Ovalocytes by themselves are harmless.  In a hereditary condition ovalocytes may constitue about 25% of red blood cells. Lesser numbers of circulating ovalocytes may be present in various anemias including megaloblastic, sideroblastic, iron deficiency, and in thalassemias.

Question 10

what does it mean for a blood smear to show moderate polychromasia and moderate schistocytes?  google doesn't give a good picture.   :)  thanks

Accepted Answer

See your doctor: See your doctor
Polychromasia is the heterogeneous staining of RBCs of different ages, with younger cells appearing blue, that occurs after haemorrhage, haemolysis, dyserythropoiesis and treatment with haematinics such as iron and vitamin B12.
Schistocytes are RBCs fragmented by their passage through intravascular strands of fibrin, found in cases of intravascular haemolysis, renal failure and thrombotic thrombocytopenic purpura amongst others.

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Doctor answers about:

What does it mean to have giant platelets on blood smear

A member asked:

What does it mean when large and giant platelets are found in blood smear, rbc morphology and poikilocytosis? what causes large and giant platelets to show up?

A member asked:

Havent been feeling well at all. blood smear showed large/giant platelets present/rbc morphology present/poikilocytosis 2+ /wbc 11.1 rbc 5.41/keystones 15, trace blood urine, bp elevation now on bp meds. what can cause those results(blood smear)?

A member asked:

What does platelet anisocytosis mean on blood smear? platelet count is 454k. (10 days ago it was 482k)

A member asked:

What does the presence of giant platelets on blood work mean ?

A member asked:

Abnormal blood smear..i have (h) wbc (l) rbc and (h) platelets and tear drop cells and helmet cells....what is this?

A member asked:

Does normal adamsts13 and normal platelet count rule out ttp from plavix ? is a blood smear , coombs and ldh required ?

A member asked:

Could a cut on my foot raise my platelets? count of 700, wbc 13, no other symptoms. found on routine cbc. blood smear clean.

A member asked:

What does it mean to have ovalocytes in a blood smear?

A member asked:

Does anyone know what it means to have ovalocytes in a blood smear?

A member asked:

What does it mean for a blood smear to show moderate polychromasia and moderate schistocytes? google doesn't give a good picture. :) thanks

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