Question 1

what chromosome carries the gene for sickle cell anemia?

Accepted Answer

Chromosome No. 11: Point mutation at  beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin.

Question 2

hiya, what are the causes of sickle cell anemia? i know it is inherited but i need it explained in a way that can tell me the causes of gene mutation.

Accepted Answer

Gene mutations: are random.   The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin.  Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection.

Question 3

could you tell me what gene is affected by sickle cell anemia?

Accepted Answer

The beta globin gene: Hemoglobin is a complicated molecule in red blood cells that carries oxygen from the lungs to the rest of the body. It contains 4 protein chains, 2 Alpha chains and 2 beta chains. Sickle cell disease is caused by specific mutation in the beta globin gene. We each have two beta globin genes. If one has the s mutation you have sickle trait; if both have the s mutation you have sickle cell anemia.

Question 4

what are the types of gene defects in sickle cell anemia?

Accepted Answer

Several: There are several genetic defects that lead to sickle cell anemia. They all lead to a change in the 6th Amino Acid in the beta-globin chain in which valine is substituted for glutamic acid. At least 5 different dna mutations have been identified that all lead to the same Amino Acid substitution, and thus, sickle cell anemia.

Question 5

help plz! can sickle cell anemia be cured with gene therapy?

Accepted Answer

Not as far I know: This may be the future.  But as of right now, I am not aware of gene therapy for sickle cell disease.  The only cure for it at the moment is bone marrow transplant.

Question 6

can you please tell me genetics of sickle cell anemia?

Accepted Answer

Inherited disease.: Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent.  This disease is more common in blacks (people of african heritage).  Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other.  Those with trait are "carriers" and are often asymptomatic.

Question 7

sickle cell anemia:is this birth defect only due to genetics?

Accepted Answer

Yes: It is a defect present from birth, yes. Would i call it a birth defect, no. It is a genetically derived abnormality in the metabolism of hemoglobin that results in sickling of the red cells under some circumstances. As a metabolic disease, it is inherited in a similar fashion to pku or cystic fibrosis. The term birth defect is more appropriate for a kid with malformation of an organ or body part.

Question 8

is sickle cell anemia purely a genetic disorder?

Accepted Answer

I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have.

Question 9

can the basic genetic defect of sickle cell anemia be treated?

Accepted Answer

Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells.

Question 10

what type of genetic disorder is sickle cell anemia or trait?

Accepted Answer

Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.).  Normal HGB consists of paired protein chains (globin) and an iron containing part (heme).  Patients with ssa inherit an abnormal beta-globin gene from each parent.  Carriers have one normal beta-globin gene and one sickle beta globin gene.  The carriers (trait) have no symptoms.

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Doctor answers about:

What chromosome carries the gene for sickle cell anemia

A member asked:

What chromosome carries the gene for sickle cell anemia?

A member asked:

Hiya, what are the causes of sickle cell anemia? i know it is inherited but i need it explained in a way that can tell me the causes of gene mutation.

A member asked:

Could you tell me what gene is affected by sickle cell anemia?

A member asked:

What are the types of gene defects in sickle cell anemia?

A member asked:

Help plz! can sickle cell anemia be cured with gene therapy?

A member asked:

Can you please tell me genetics of sickle cell anemia?

A member asked:

Sickle cell anemia:is this birth defect only due to genetics?

A member asked:

Is sickle cell anemia purely a genetic disorder?

A member asked:

Can the basic genetic defect of sickle cell anemia be treated?

A member asked:

What type of genetic disorder is sickle cell anemia or trait?

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