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what chromosome carries the gene for sickle cell anemia

A 30-year-old member asked:
Dr. Jay Park
Dr. Jay Park answered
49 years experience Pediatrics
Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin.
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A 21-year-old female asked:
Dr. Michael Gabor
32 years experience Diagnostic Radiology
Gene mutations: are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is ... Read More
A 55-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
The beta globin gene: Hemoglobin is a complicated molecule in red blood cells that carries oxygen from the lungs to the rest of the body. It contains 4 protein chains, 2 Al ... Read More
A 41-year-old member asked:
Dr. Steven Ginsberg
36 years experience Hematology and Oncology
Several: There are several genetic defects that lead to sickle cell anemia. They all lead to a change in the 6th Amino Acid in the beta-globin chain in which v ... Read More
A 37-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
11: The beta globin gene is mutated in sickle cell anemia; it is located on chromosome 11.
A 52-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of t ... Read More
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A 40-year-old member asked:
Dr. Steven Ginsberg
36 years experience Hematology and Oncology
Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficu ... Read More
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A 48-year-old member asked:
Dr. Charles Greenberg
44 years experience General Practice
Blood: The genetic defect is in the hemoglobin molecule.
A 55-year-old member asked:
Dr. Scott Diede
28 years experience Pediatric Hematology and Oncology
No: Sickle cell trait is when a person has one mutated copy of the beta-hemoglobin gene and one normal copy. You always inherit the mutated hemoglobin fro ... Read More
A 42-year-old member asked:
Dr. Steven Ginsberg
36 years experience Hematology and Oncology
Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having ... Read More
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A 48-year-old member asked:
Dr. Scott Diede
28 years experience Pediatric Hematology and Oncology
No: The vast majority of patients with sickle cell trait have no health consequences whatsoever.
A 41-year-old member asked:
Dr. Martin Rubenstein
44 years experience Hematology and Oncology
Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing par ... Read More
A 47-year-old member asked:
Dr. Maulik Shah
23 years experience Clinical Genetics
Carrier vs. Affected: Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s ... Read More
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A 54-year-old member asked:
Dr. Jeffrey Unger
40 years experience Family Medicine
No: Malaria is an infectious disease transmitted by mosquitoes. Sickle cell is a genetic disorder resulting in a disruption in the oxygen carrying capacit ... Read More
A 48-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of t ... Read More
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A 54-year-old member asked:
Dr. James Ball
18 years experience Pediatric Hematology and Oncology
No. : Blood transfusions will not cause sickle trait. Sickle trait is an inherited disease. You will get it from one of your parents.
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A 29-year-old member asked:
Dr. Richard Orr
43 years experience Surgical Oncology
40-50 years: One survey i found stated that the median life expectancy for people with sickle cell disease is 42 years for men and 48 years for women. Keep in min ... Read More
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A 46-year-old female asked:
Dr. Gurmukh Singh
48 years experience Pathology
Contradiction in: terms. WBCs do not have sickle cell disorder. Sickle cell disorder is due to a variant hemoglobin and only RBCs have hemoglobin in any quantity to und ... Read More
A 51-year-old member asked:
Dr. Kelty Baker
27 years experience Hematology
Sickle cell trait: Sickle cell trait can be diagnosed by a heel stick at birth or by performing hemoglobin electrophoresis of the blood (a simple blood test).
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A 38-year-old member asked:
Dr. Liawaty Ho
22 years experience Hematology and Oncology
Same: Sickle cell anemia is sickle cell disease.
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A 29-year-old female asked:
Dr. Le Wang
Dr. Le Wang answered
35 years experience Internal Medicine
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has ... Read More
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A 49-year-old member asked:
Dr. James Ball
18 years experience Pediatric Hematology and Oncology
Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disea ... Read More

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