Question 1

what are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?

Accepted Answer

Same aa sequence: tPA and its recombinant version (Activase) are identical with respect to the amino acid sequence.  There have been reported some minor differences with respect to glycosylation of the protein, but this is well within the specifications of the cGMP production by the manufacturer.

Question 2

when someone goes to an emergency room in an ambulance can a worker administer iv tpa (tissue plasminogen activator) to meet the golden hour of door-to-needle? or, a ct in hospital is a must as protocol first?

Accepted Answer

Doctor: Evaluation by a doctor has to precede  a treatment like tPa or other thrombolytics.
Have a healthy diet, exercise 30 minutes/day, drink plenty of water, have safe sex, no tobacco alcohol weed or street drugs. For nutrition: http://www.choosemyplate.gov/.
Wish you good health!

Question 3

what are tissue plasminogen activators used for?

Accepted Answer

Dissolve blood clots: These are proteins that when added to blood bind to clots and dissolve them.

Question 4

iga 40,ferritin 5, ana1:160 homogeneous, prothrombin2, plasminogen, mthfr mutation, tia in may. for yrs: low grade fever, swollen nodes,fatigue off/on but worsening,m.pneumonia 1700 for2 yrs,asthma worse,(not worried @covid neg 2x) want to feel well?

Accepted Answer

Specialists: You don't mention your age, but if you're on the young side,  your syndrome appears to have features of a vasculitis in view of the TIA history, lung symptoms and ANA titer. For this reason I recommend having a rheumatologist involved in your care. I wonder if a biopsy of your lymph nodes has been done to check for systemic vasculitis or whether the nodes only show nonspecific reactive changes.

Question 5

my mother is suffering from acute ischemic stroke, she is diabetic, her late arrival to the hospital made situation bad since none of the initial tissue activator were given to her.how can i manage her health situation ?

Accepted Answer

You can't on ur own: First, I am sorry for what happened to your mother, and wish her recovery and health. Second, this a complex health situation, a team approach of physicians, nurses, physical therapist, rehab specialists, helpers, social workers would all act together, your part would be to coordinate her care being a loving and caring son, hope all or part of those facilities are available for your mother,

Question 6

is streptokinase a clot buster?

Accepted Answer

Yes: It is, but we almost never use it in the US any longer.

Question 7

what is a difference between calcium channel blocker and clot buster?

Accepted Answer

Apples vs. oranges: They are both cardiac medicines. They are however used for totally different reasons. Calcium blockers are most commonly used to treat high blood pressure. They may also be used to treat chest pain or to slow the heart. Clot busters are used to dissolve a clot in the arteries that supply blood to the heart itself and therefore to limit the amount of heart damaged by removing the blockage.

Question 8

can pregnant women use alteplase injections?

Accepted Answer

Contraindication: It can cause hemorrhage any where in body. It is contraindicated in pregnancy

Question 9

could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Accepted Answer

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding.  One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began.  Another is to administer it right where it is needed, near the location of the artery which contains the clot.

Question 10

how effective are alteplase injections for treating stroke?

Accepted Answer

FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html &amp; http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation).

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Doctor answers about:

Tissue plasminogen activator

A member asked:

What are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?

A member asked:

When someone goes to an emergency room in an ambulance can a worker administer iv tpa (tissue plasminogen activator) to meet the golden hour of door-to-needle? or, a ct in hospital is a must as protocol first?

A member asked:

What are tissue plasminogen activators used for?

A member asked:

Iga 40,ferritin 5, ana1:160 homogeneous, prothrombin2, plasminogen, mthfr mutation, tia in may. for yrs: low grade fever, swollen nodes,fatigue off/on but worsening,m.pneumonia 1700 for2 yrs,asthma worse,(not worried @covid neg 2x) want to feel well?

A member asked:

My mother is suffering from acute ischemic stroke, she is diabetic, her late arrival to the hospital made situation bad since none of the initial tissue activator were given to her.how can i manage her health situation ?

A member asked:

Is streptokinase a clot buster?

A member asked:

What is a difference between calcium channel blocker and clot buster?

A member asked:

Can pregnant women use alteplase injections?

A member asked:

Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

A member asked:

How effective are alteplase injections for treating stroke?

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