A 41-year-old member asked:
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what are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?

1 doctor answer
Dr. Bert Liang
Specializes in Neurology
Same aa sequence: tPA and its recombinant version (Activase) are identical with respect to the amino acid sequence. There have been reported some minor differences with respect to glycosylation of the protein, but this is well within the specifications of the cGMP production by the manufacturer.
Answered on Mar 28, 2017

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