Question 1

what is the definition or description of: rnp antibody?

Accepted Answer

Anti-RNP: Evaluating patients with signs and symptoms of a connective tissue disease in whom the test for antinuclear antibodies is positive.

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357.

Question 2

positive for rnp antibody but negative for smith antibody and sm/rnp antibody? what is the difference between sm/rnp and rnp?

Accepted Answer

: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, both of these auto-antibodies are markers for SLE, however, neither diagnostic in itself.   
For info: https://www.hopkinslupus.org/lupus-info/diagnosing-lupus/#:~:text=The%20ACR%20criteria

Question 3

given a positive rnp antibody test, what are the clinical diagnostic criteria for mctd?

Accepted Answer

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands.

Question 4

had lab test done.  sm/rnp antibody   2.5 pos.   what does this mean?

Accepted Answer

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place?

Question 5

can there be false positive rnp antibody tests even with a high titre of an ana?

Accepted Answer

FALSE POSITIVE RNP: It is possible
we need to know what your symptoms and signs are, and why the tests have been ordered.The lab test apways have to be interpreted along with complete clinacal findings
if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive.That in all probabilities is positive and not false positive.

Question 6

i'm having negative dna ,sm and rnp antibodies, but positive sm/rnp antibody,and high ana titre speckled,so what is the diagnosis ?

Accepted Answer

Lupus: These serologies are rather non specific.  The speckled ANA is non specific.  In Systemic Lupus Erythematosis  (SLE) it is usually homogeneous in its staining.  Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis.  As often is the case a specific diagnosis cannot be made.  You need to see a Rheumatologist.

Question 7

i had the following test results- what do they mean?  rfactor -7, ana choice screen - positive, rnp antibody- 2.0, dna da antibody 5

Accepted Answer

Possibly nothing: The ANA screen is positive but one needs a full titer and pattern to know what it means. The other results are flatly negative.

Question 8

sm/rnp antibody- ana choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Accepted Answer

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment.

Question 9

positive ana at 1:640, speckled pattern and rnp antibody of 59.  w/raynauds.  what is next?

Accepted Answer

Rheumatology evaluat: It could be an overlap syndrome but you need a full of evaluation

Question 10

rnp antibody, speckled pattern, titer of 1:320.  no symptoms or anything. high complement c3 & c4 levels. do i have an autoimmune disease?

Accepted Answer

Not necessarily: Do you have any symptoms? If you do not, stay in touch with your doctor for follow-up care. An abnormal lab results does not make it auto-immune disease, but it does put you at a greater risk.
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Doctor answers about:

Rnp antibody

A member asked:

What is the definition or description of: rnp antibody?

A member asked:

Positive for rnp antibody but negative for smith antibody and sm/rnp antibody? what is the difference between sm/rnp and rnp?

A member asked:

Given a positive rnp antibody test, what are the clinical diagnostic criteria for mctd?

A member asked:

Had lab test done. sm/rnp antibody 2.5 pos. what does this mean?

A member asked:

Can there be false positive rnp antibody tests even with a high titre of an ana?

A member asked:

I'm having negative dna ,sm and rnp antibodies, but positive sm/rnp antibody,and high ana titre speckled,so what is the diagnosis ?

A member asked:

I had the following test results- what do they mean? rfactor -7, ana choice screen - positive, rnp antibody- 2.0, dna da antibody 5

A member asked:

Sm/rnp antibody- ana choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

A member asked:

Positive ana at 1:640, speckled pattern and rnp antibody of 59. w/raynauds. what is next?

A member asked:

Rnp antibody, speckled pattern, titer of 1:320. no symptoms or anything. high complement c3 & c4 levels. do i have an autoimmune disease?

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