Question 1

what causes retinoblastoma?

Accepted Answer

RB gene mutation: Inherited or acquired loss of both copies of the retinoblastoma gene leads to uncontrolled proliferation of cells and can cause many cancers, including retinoblastoma.

Question 2

how is retinoblastoma cured?

Accepted Answer

Aggressive: Depends on size and location, small tumors are treated with laser surgery.Radiation for larger tumors. Chemotherapy if tumor has spread beyond the eye. The eye may need to be removed if the tumor does not respond to other treatments. If cancer has not spread beyond the eye, almost all patients can be cured.

Question 3

how is a retinoblastoma caused?

Accepted Answer

Chromosme 13: Has a paired site where the rb gene lives.  It can be inherited, or occur accidentally (sporadic) mutation.  The rb gene loss leads to the eye tumor, but it is also is involved with other tumors, and its chromosomal location is close to a region associated with bone tumors.

Question 4

what is retinoblastoma diagnosis?

Accepted Answer

Eye exam: It is diagnosed by an eye exam supported by imaging studies. No blood tests to diagnose it. Getting a good history, and physical exam are in order

Question 5

can you tell me about retinoblastoma?

Accepted Answer

Yes...: Retinoblastoma is an eye cancer that begins in the retina — the sensitive lining on the inside of your eye. Retinoblastoma most commonly affects young children, but can rarely occur in adults. Retinoblastoma may occur in one or both eyes. There are good treatments if caught early and if it has not spread outside of the eye.

Question 6

does retinoblastoma stay in one place?

Accepted Answer

Not always: There is a risk of metastasis of retinoblastoma to adjacent structures or to distant sites via hematogenous metastasis.

Question 7

what are the symptoms of retinoblastoma?

Accepted Answer

Vision symptoms: There are many different symptoms, but most are changes in vision or eye function. A white pupil, redness of the eye, different directions of gaze. However, these are non-specific, and additional studies and tests have to be performed to make sure of the diagnosis before treatment begins.

Question 8

what are the odds to get retinoblastoma?

Accepted Answer

Low: Extremely low risk for adults, because the retinal cells stop dividing in childhood.People with heritable(germ line) retinoblastoma are at a higher risk for other cancers throughout their lives , making genetic testing very important.It affects smaller children.

Question 9

how can i get trilateral retinoblastoma?

Accepted Answer

See below for info: Retinoblastoma is a cancer of the eye.  Like other cancers, it occurs when a cell 'goes bad' -- ie turns malignant and keeps multiplying.  Unilateral would be in one eye, bilateral would be in both eyes.  Trilateral would mean in 3 eyes, which isn't possible, since you have only 2 eyes.

Question 10

what should i know about retinoblastoma?

Accepted Answer

Rare tumor: This rare eye cancer is sometimes caused by a genetically inherited abnormality. These cancers should be treated by centers of excellence that specialize in treating this rare cancer. Surgery or radiation therapy (proton beam or brachytherapy) are the most common treatment options.
http://www.cancer.gov/cancertopics/types/retinoblastoma.

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