Question 1

which is best? prolia or reclast (zoledronic acid)

Accepted Answer

Talk to your doctor: Those drugs work differently. Both have side effects. Your doctor can assess the potential benefits and risks for you, taking into account your health, including other conditions. If uncertain, consider second opinion from an osteoporosis specialist.

Question 2

what medication has less side effects prolia  or reclast (zoledronic acid)?

Accepted Answer

Prolia: Both medications are anti-resorptive, meaning they prevent breakdown of your bone.  Reclast (zoledronic acid) has been used for longer so has more side-effects that are known.  It also can not be used if you have kidney problems.  Prolia is an injection every 6 months (vs. 12 months with reclast).  Both medications tend to be very well tolerated.

Question 3

for me, 3 yrs ago reclast=5% improvement, prolia for 2 yrs=little improvement, but 10% loss hip neck! why? and, now must be off for 3 yrs, scary! thx!

Accepted Answer

Treating osteoporosi: Reclast (zoledronic acid) is an antiresorptive medication (like Fosamax, Boniva, etc) that is given IV.  It will prevent further loss but will not rebuild bone.  5-10% increase/decrease is likely within the margin of error of a DEXA scan.   Recombinant human parathyroid hormone rPTH (Forteo) is an injectable medication that does rebuild bone and increase density.  rPTH cannot be given with a history of cancer.

Question 4

took fosomax for 7 years with little benefit; then no meds for 2 years.  which has best risk/benefit ratio:  reclast, (zoledronic acid) prolia, fortero, foxomax?

Accepted Answer

Supplements: These natural substances help build bones naturally:
strontium, boron, vit d3, magnesium, and calcium. 
Eating lots of alkalizing foods such as fruit and vegetables also helps.

Question 5

which drug would you choose for osteoporosis of hip  prolia or reclast (zoledronic acid)    what is better tolerated less side effects?

Accepted Answer

Depends: Both drugs are effective in the treatment of osteoporosis involving the hip.  Prolia is likely to work better than reclast, (zoledronic acid) though there are no head to head studies comparing the two.  Prolia is typically used in people who have had a previous fracture (spine, wrist), or have very severe osteoporosis. Both are well tolerated with few side effects.  Prolia is given twice yearly, Reclast (zoledronic acid) once yearly.

Question 6

my doctor recommended reclast (zoledronic acid) for" convenience." i'm only concerned about the risks/benefits of a drug. should i choose prolia or fosomax instead?

Accepted Answer

Alendronate is good.: Oral bisphosphonates are generally first line agents becuase of efficacy, price and long term safety record.  Alendronate once a week or risedronate are good choices.  The other meds are second line.

Question 7

took fosomax for 7 yrs with little benefit (slightly worse each yr), then no meds x2 yrs.  which has best risk/benefit ratio:  reclast, (zoledronic acid) prolia, fosomax?  ctx test results >300 so md eliminated forteo.

Accepted Answer

Reclast (zoledronic acid) maybe: The reccommendation now is to have 5 yrs of a bisphosphnate-you had 7.  The point of the therapy is to prevent further deterioration not necessarily to improve it.  If Forteo is not an option the best might be Reclast (zoledronic acid) as is it given by IV and will have the best absorption. Prolia has merit as well but has many more potential side effects that you need to review with your doctor.

Question 8

what are considered the benefits of having denosumab injections?

Accepted Answer

Treat osteoporosis: Denosumab is an antibody that works in a way similar to bisphosponates (like fosamax) to decrease bone turnover and decrease the risk of fractures in people with osteoporosis who have had a previous fracture.  Studies suggest that it is more effective than bisphosphonates.  In your age group, unless you have severe osteoporosis or a previous fracture, you would not be a candidate for it.

Question 9

is prolia best for osteoporosis?

Accepted Answer

Maybe: Prolia represents a new category of osteoporosis treatment that is effective and has convenient twice yearly dosing.  It appears much more effective than the bisphosphonates and rivals Forteo with much more convenience.  It is expensive if not covered by your insurance.  Whether it is best for you or not depends on many factors which would require more information about a specific patient.

Question 10

what are the active ingredients in prolia?

Accepted Answer

Only one: Hi. The only active ingredient in Prolia is denosumab, a monoclonal antibody that binds a signaling molecule, RANK Ligand (RANKL), that bone forming cells (osteoblasts) secrete that activates bone resorbing cells (osteoclasts). RANKL activates the osteoclasts to break down bone. Denosumab interrupts that, and preserves bone mass and architecture.

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Doctor answers about:

Prolia vs reclast

A member asked:

Which is best? prolia or reclast (zoledronic acid)

A member asked:

What medication has less side effects prolia or reclast (zoledronic acid)?

A member asked:

For me, 3 yrs ago reclast=5% improvement, prolia for 2 yrs=little improvement, but 10% loss hip neck! why? and, now must be off for 3 yrs, scary! thx!

A member asked:

Took fosomax for 7 years with little benefit; then no meds for 2 years. which has best risk/benefit ratio: reclast, (zoledronic acid) prolia, fortero, foxomax?

A member asked:

Which drug would you choose for osteoporosis of hip prolia or reclast (zoledronic acid) what is better tolerated less side effects?

A member asked:

My doctor recommended reclast (zoledronic acid) for" convenience." i'm only concerned about the risks/benefits of a drug. should i choose prolia or fosomax instead?

A member asked:

Took fosomax for 7 yrs with little benefit (slightly worse each yr), then no meds x2 yrs. which has best risk/benefit ratio: reclast, (zoledronic acid) prolia, fosomax? ctx test results >300 so md eliminated forteo.

A member asked:

What are considered the benefits of having denosumab injections?

A member asked:

Is prolia best for osteoporosis?

A member asked:

What are the active ingredients in prolia?

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