Question 1

how many types of osteogenesis imperfecta are there?

Accepted Answer

There are 8 types: Dominantly Inherited
Type I:Mildest form ~ 50% of total. 
Type II:Most severe form. High mortality rate
Type III:Most severe type who survives neonatal period.
Type IV: Moderate-severe growth retardation
Type V: Moderate in severity. Hypertrophic calluses
Type VI:Rare.Similar symptoms to OI Type IV
Resessively inherited  Types VII and VIII
Type VII resembles  IV and II
Type VIII similar to II, III

Question 2

is there a cure for osteogenesis imperfecta?

Accepted Answer

A genetic disorder: Osteogenesis imperfecta is a group of disorders that cause bone fragility due to an error in the genetic code for type i collagen. All tissues that are composed of type i collagen are affected. There are many subtypes ranging in severity and associated comorbidities, but all include fragile bones. There is no cure yet.

Question 3

what are treatments for  osteogenesis imperfecta?

Accepted Answer

It varies: Milder forms can be observed and take precautions to reduce the risk of fracture. The more severe forms may require surgery in childhood to treat the fractures and keep the bones relatively straight. Very severe cases can be fatal. See an specialist who cares for this, such as a pediatric orthopedist (for children with oi).

Question 4

why are sclera blue in osteogenesis imperfecta?

Accepted Answer

Thinner sclera: The white part of the eyeball is the sclera. In osteogenesis imperfecta, the person has a genetic mutation that causes him to make defective connective tissues and/or not enough connective tissues. The eyeball sclera is made of connective tissue, but it is thinner in an o.I. Person, so it looks bluish instead of white.

Question 5

is osteogenesis imperfecta brittle bone disease?

Accepted Answer

Yes: They are the same - caused by a genetic mutation.

Question 6

what causes the blue sclera in osteogenesis imperfecta oi?

Accepted Answer

Uveal "show": Oi causes a thinning of the sclera, the white coat of the eye. It allows the blue-gray uveal layer beneath to be visible through the sclera.

Question 7

can surgery cure hearing loss from osteogenesis imperfecta?

Accepted Answer

Yes: Osteogenesis imperfecta is often associated with otospongiosis (otosclerosis) which can lead to fixation of the stapes bone.  This fixation of the stapes bone can manifest as a conductive hearing loss.  If stapes fixation is thought to be the cause of the conductive loss, corrective surgery on the stapes can be helpful especially if there is sufficient cochlear reserve.

Question 8

what can lead to the blue sclera in osteogenesis imperfecta?

Accepted Answer

It doesn't: Where the sclera is thin, it appears blue from the deoxygenated blood the choroidal blood vessel layter next tot he sclera.  This is normal in patients who are nearsighted.

Rarely, this is a sign associated with osteogenesis imperfecta.  Not a cause.  Not diagnostic.

Question 9

can osteogenesis imperfecta affect more than just bone structure?

Accepted Answer

YES...: This is a condition that affects all bones in the body - with a great degree of variability amongst patients in the severity of the disease. There are several types known, and symptoms are quite different depending on the type. What is common is the brittle bone - in mild forms the fractures occur in childhood and stop after adulthood. Some patients have hearing loss/tooth problems.

Question 10

what causes the blue sclera in people with osteogenesis imperfecta?

Accepted Answer

Osteogenesis imperfe: This classic finding in osteogenesis imperfecta is due to thin connective tissue in the sclera. However, children may have slightly blue tinted sclera without having oi.

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