Question 1

my kappa flc count is a 2.17 mg/dl (range on test is .33 - 1.94 mg/dl) and my lambda count is 1.31 mg/dl (range is .57 - 2.63 mg/dl) ratio is 1.66 (range .26 - 1.65) spep is normal? should i be worried about ratio being .01 outside of normal range?

Accepted Answer

: Although the ratio is only .01 above the upper limit of normal but serum kappa FLC is high so the result has to be interpreted cautiously. I wonder if you have 24 hour urine collection and or urine immunofixation. If kappa light chain is high in the urine, kappa light chain disease may be present. I assume your kidney function is still normal because those light chains are much higher in CKD.

Question 2

kappa/lambda flc ratio high (2.75) w/ normal k(10.21mg/dl) & low l(3.68mg/dl). hem-onc unsure if ratio implies k monoclonality since serum/urine ife ok & neither chain is elevated. could monoclonal k be suppressing l? iga a bit high igg &igm a bitlow

Accepted Answer

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738
At your age you are unlikely to have myeloma.

Question 3

what does a high kappa/lambra ratio mean?

Accepted Answer

Multiple Myeloma: Kappa and lamda are classifications of light chains of immunoglobulins in humans.  They are part of the "y" shaped arms of your antibodies.  This ratio is used to distinguish MGUS or monoclonal gammopathy of undetermined significance from multiple myeloma. High ratio favors Multiple Myeloma

Question 4

if an igg kappa paraproteinaemia is measured as 7g?

Accepted Answer

Hopefully 7mg/L: It also depends on the ratio of kappa to lamda light chains and the presence of polyclonal or monoclonal gammopathy.That is a large amount, while 7mg/l would be normal. Please double check the measurement for grams or milligrams.

If abnormal, it can mean a plasma cell dyscrasia like multiple myeloma, amyloidosis, or Waldenstrom's anemia. Please follow up with the doctor who ordered the test.

Question 5

light chains kappa 55% & lambda 39%. what are the range values?

Accepted Answer

Http://myeloma.org/pdfs/U-Freelite-Eng2011_g2web.pdf: Go to the website above for good summary of KAPPA and LAMBDA values, and significance;;

Normal levels of serum free light chains are*:
• Kappa: 3.3–19.4 mg/L*
• Lambda: 5.71–26.3 mg/L*
• Kappa/lambda ratio: 0.26–1.65**
*Note: The units here are mg/L; different
laboratories use different units. It is important to
double-check the units used when comparing
numbers in lab values.
**Further Note: In patients with renal impairment,
it is recommended to interpret the results
of the Kappa/Lambda ratio with a modified
reference range of 0.37–3.1.

Question 6

my kappa is 89.0, lambda is 52.5 and ratio is 1.70. should i be concerned?

Accepted Answer

Need more info: What did your serum protein electrohphoresis show? What is your serum creatinine level?  What is your hemoglobin level? Do you have any symptoms? Was a bone  x-ray done? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests.

Question 7

had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. thoughts?

Accepted Answer

I'm not sure I could: make much of a prognostic distinction between an abnormal kappa/light chain ratio and kappa elevation. Produced within plasma cells, heavy and light chains bind together to form immunoglobulins. Typically producing more light chains than required ,the plasma cells enter the blood as free light chains. The activity of myeloma/plasma cell growth is linked to the amount of free light chains in blood.

Question 8

hello,  my dr. told me my kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should i ask /?

Accepted Answer

Sounds reasonable: You have a minimal degree of change, this may be within the normal range. But a recheck of this test is a good idea just to be sure. it is a rare condition that you do not need to worry about unless you have some symptoms in the future.Do tell us your age as some  such conditions primarily occur in older adults

Question 9

my kappa- lambda ratio 2.2, is that high?

Accepted Answer

Somewhat: That ratio is elevated and may represent some problem with your kidneys or your blood elements. The results need to be evaluated along with a protein electrophoresis test of your blood for more solid information. Contact whoever ordered the test and ask what they feel it represents and what further testing you may need, especially if you know your kidney function is normal.

Question 10

is igg kappa only associated with multiple myloma?

Accepted Answer

No: It is also associated with B cell lymphoma, amyloidosis, monoclonal gammopathy of undetermined significance, mycobacterium infection, superficial thrombophlebitis, and some inflammatory conditions among other things.

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Doctor answers about:

Kappa FLC

A member asked:

My kappa flc count is a 2.17 mg/dl (range on test is .33 - 1.94 mg/dl) and my lambda count is 1.31 mg/dl (range is .57 - 2.63 mg/dl) ratio is 1.66 (range .26 - 1.65) spep is normal? should i be worried about ratio being .01 outside of normal range?

A member asked:

Kappa/lambda flc ratio high (2.75) w/ normal k(10.21mg/dl) & low l(3.68mg/dl). hem-onc unsure if ratio implies k monoclonality since serum/urine ife ok & neither chain is elevated. could monoclonal k be suppressing l? iga a bit high igg &igm a bitlow

A member asked:

What does a high kappa/lambra ratio mean?

A member asked:

If an igg kappa paraproteinaemia is measured as 7g?

A member asked:

Light chains kappa 55% & lambda 39%. what are the range values?

A member asked:

My kappa is 89.0, lambda is 52.5 and ratio is 1.70. should i be concerned?

A member asked:

Had abnormal k/ light chain ratio six months ago; now ratio is wnl, but kappa level remains elevated three blood panels later. thoughts?

A member asked:

Hello, my dr. told me my kappa light chain is elevated at 26.. she told me not to worry and we'll check again in 3 months.. what else should i ask /?

A member asked:

My kappa- lambda ratio 2.2, is that high?

A member asked:

Is igg kappa only associated with multiple myloma?

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