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Is it okay to take amitriptyline with a low dose of Tramadol for pain

A 34-year-old member asked:
Dr. Sassan Hassassian
28 years experience Anesthesiology
Physician can decide: Tramadol and Amitriptyline both exert some effect on serotonin containing nerve pathways. There is potential interaction between the two. Treating p ... Read More
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A 51-year-old member asked:
Dr. William Newton
18 years experience Pain Management
Not recommended: The combination of the these two medications together can potentially increase levels of serotonin which can lead to serotonin syndrome which can be l ... Read More
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A 43-year-old member asked:
Dr. Mark Reynolds
32 years experience Psychiatry
Usually: While it is generally safe to use the medications in combination, there is a slight risk of developing serotonin syndrome. Serotonin syndrome is chara ... Read More
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A 41-year-old male asked:
Dr. Paul Grin
Dr. Paul Grin answered
35 years experience Pain Management
Not recommended: Tramadol and alcohol are depressant of the central nervous system. Mixing tramadol with alcohol could lead to drowsiness to severe depression of brain ... Read More
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A 50-year-old member asked:
Dr. Marc Zimmermann
21 years experience Psychiatry
Yes: While these medications can potentiate each other, they are usually safe to use together. Consult your prescriber to be sure it is safe for you.
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A 54-year-old member asked:
Dr. Charles Nemeroff
39 years experience Psychiatry
Yes: Yes but can both be sedating.
A 29-year-old female asked:
Dr. Ki-Hon Lin
24 years experience Orthopedic Surgery
Yes: That should be fine. I have generally seen the Amitriptyline prescribed for night time use, whereas the tramadol (which, at 300 mg i'm assuming is an ... Read More
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A 31-year-old female asked:
Dr. Krishna Kumar
54 years experience Psychiatry
Medication effects: Amitriptyline is medication for Depression. Thank you for informing about use of Xanax (alprazolam). Using amitriptyline with Xanax (alprazolam) may i ... Read More
A 60-year-old member asked:
Dr. Adam Elisha
6 years experience Rheumatology
Medication Cocktail: Assuming these are taken at appropriate doses and prescribed by your provider, this is a fairly common combination for management of chronic pain.
A 32-year-old female asked:
Dr. Brian Clear
11 years experience Family Medicine
Sedating medications: Elavil (amitriptylene), tramadol, and Flexeril (cyclobenzaprine) are all sedating and if taken together in someone who's not used to them could indeed ... Read More

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