Question 1

i have palpitations and back headache feeling like heavy and dizziness,blurred vision in 2d echo found mitral valve prolapse aml &pml prolapse all are normal except this is this related or anything else?

Accepted Answer

: Prolapse of the mitral valve does predispose you to atrial irritability in the form of premature atrial beats ,runs of supraventricular tachycardia including atrial fibrillation. I'm not sure your mitral valve prolapse is responsible for your symptoms unless you had a bout of sustained atrial irritability during the symptoms. If those symptoms recur in the absence of palpitations,see a neurologist

Question 2

if you had a negative mds and aml panel chromosome and fish panel in 2021 can those panels be positive one year later? still having anemia low platelets low white cell. no spleen enlargement. dr. believes it is myelofibrosis?

Accepted Answer

: They may have new tests up use every once in a while.  Sometimes it is not possible to say for certain what you have until it evolves some more.  Time will tell.

As one of my old professors used to say: I never told you medicine is easy. In the mean time I would find something you like and can do and do it. Worrying usually does not help.

Question 3

can leukemia cells be dormant in the body? been having elevated wbc/ low rbc & high imm gran for 8mths platelets low 3mths but restored.mpv levels are still high. recent bone marro biop/ chromosome/fish/ antibodies test/ neg aml & mds could it be cml?

Accepted Answer

: Sure. But REALLY need to have a long talk with your Hematologist/Oncologist. May be hard for him/her to make the time, but this is the wrong forum for that discussion

Question 4

what are the symptoms associated with pml?

Accepted Answer

PML: Progressive multifocal leukoencephalopathy is a rapidly progressive viral infection of the brain caused by creutzfeldt jacob papova virus which affect support cells of the brain. Causes headaches, memory loss, speech & vision difficulties, changes in mental status, seizures, partial paralysis, limb weakness, incoordination, and finally coma & death.

Question 5

is pml reversible? i am beginning tecfidera and the warning labels are intimidating.

Accepted Answer

If I understand your: question, you have PML--clearly a very rare and debilitating viral disease--and your are wondering if anything can "reverse" it. My understanding is that there are no truly effective drugs that cure or reverse PML. Tecfidera is typically used in multiple sclerosis; perhaps your neurologist is suggesting you might try it due to some trial or clinical evidence of benefit. Very individual decision.

Question 6

how many different ways are there to correctly and positively diagnose the brain virus pml:?

Accepted Answer

Approaches: Can do a blood test to screen, an anti-JCV antibody index, but if the disease is present MRI of brain shows characteristic patterns, and spinal fluid PCR testing can be very positive.

Question 7

is there a gentle way to treat pml?

Accepted Answer

NO: Pml is caused by the jc virus. It can lie dormant in an immunocompetent host for a lifetime. In the immunocompromised host, pml is uniformly fatal without reconstitution of the immune system. There have been several reports of antiviral agents being used to treat pml in immunocompromised states, the numbers are very limited and the treatment is not gentle. To answer your question...No.

Question 8

how do we prevent pml?

Accepted Answer

Assuming you have ms: Assuming you mean progressive multifocal leukoencephalopathy, and assuming you are on tysabri, (natalizumab) your dr. Now has the availability of serum titters to see if you are at risk.  If you are, the only means of prevention is to follow titters.

Question 9

how common is pml from rituxan (rituximab) for lymphoma?

Accepted Answer

Rituximab: Progressive multi focal leukoencephalopathy  (PML) can be associated with Rituximab treatment and with other drugs which cause immunosuppression. It is s rare complication. In one study 52 cases were reported in patients with lymphoma and other myeloproliferative diseases. The incidence was less than 1%. However the drug is being used more and more and the incidence may increase.

Question 10

what is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?

Accepted Answer

Different problems: Pml is a viral disease affecting the brain and occurs in patients with compromised immune systems such as those with aids, transplants, cancer, etc. Rpls is a reversible syndrome of headaches, seizures, confusion, and other symptoms due to medications, high blood pressure, etc. And improves upon treatment of the underlying disorder.

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Doctor answers about:

Fluorescence in situ hybridization, aml m3, pml/rara

A member asked:

I have palpitations and back headache feeling like heavy and dizziness,blurred vision in 2d echo found mitral valve prolapse aml &pml prolapse all are normal except this is this related or anything else?

A member asked:

If you had a negative mds and aml panel chromosome and fish panel in 2021 can those panels be positive one year later? still having anemia low platelets low white cell. no spleen enlargement. dr. believes it is myelofibrosis?

A member asked:

Can leukemia cells be dormant in the body? been having elevated wbc/ low rbc & high imm gran for 8mths platelets low 3mths but restored.mpv levels are still high. recent bone marro biop/ chromosome/fish/ antibodies test/ neg aml & mds could it be cml?

A member asked:

What are the symptoms associated with pml?

A member asked:

Is pml reversible? i am beginning tecfidera and the warning labels are intimidating.

A member asked:

How many different ways are there to correctly and positively diagnose the brain virus pml:?

A member asked:

Is there a gentle way to treat pml?

A member asked:

How do we prevent pml?

A member asked:

How common is pml from rituxan (rituximab) for lymphoma?

A member asked:

What is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?

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