Question 1

what is metachromatic-leukodystrophy? what causes it?

Accepted Answer

A genetic disorder: Metachromatic leukodystrophy is an inherited disorder characterized by the accumulation of fats called sulfatides in cells. This accumulation especially affects cells in the nervous system that produce myelin, the substance that insulates and protects nerves
This is a link to the genetic website with more information
http://ghr.nlm.nih.gov/condition/metachromatic-leukodystrophy

Question 2

does leukodystrophy cause extreme tiredness?

Accepted Answer

Yes : Yes, it can cause significant fatigue.

Question 3

what is leukodystrophy?

Accepted Answer

Childhood: This is a class of hereditary disorders affecting the white matter of the brain mainly presenting in childhood.  The diseases may vary in extent and pace, but often affect walking, cognition, and may be associated with epilepsy.  More information may be found on mayo clinic site or www.Aan.Com.

Question 4

can leukodystrophy be sex-linked?

Accepted Answer

Yes: A few are known include the well-known adrenoleukodystrophy.

Question 5

what is metachromatic leukodystrophy?

Accepted Answer

MLD: Is a lysosomal storage disease affecting myelin growth, the insulator of nerve fibers, affecting lipid metabolism. It leads to progressive dementia in adults.

Question 6

what are the tests for leukodystrophy?

Accepted Answer

Leukodystrophy tests: Neurodevelopmental tests demonstrate the following findings in patients with infantile or early juvenile metachromatic leukodystrophy:

•loss of previously achieved developmental milestones
•tremors
•truncal ataxia
•hyperreflexia progressing to hyporeflexia
•hypotonia
•gait abnormalities
•optic atrophy
neurocognitive tests demonstrate other abnormalities.

Question 7

what exactly is aldrino leukodystrophy?

Accepted Answer

Genetic disorder: Adrenoleukodystrophy is genetic disorder that mainly affects males and results in the accumulation of very-long chain fatty acids in tissues throughout the body, mainly the central nervous system and the adrenal cortex, causing progressive neurodegenrative changes and adrenal insufficiency respectively. Prognosis not good unfortunately.

Question 8

what are the symptoms of leukodystrophy?

Accepted Answer

Leukodystrophy signs: •gait disturbances
•memory deficits
•seizures (may be present)
•loss of motor developmental milestones
•decreased attention span
•speech disturbances
•decline in school performance
the early juvenile form includes the following:

•gait disturbances
•tremors
•clumsiness
•loss of previously achieved skills
•intellectual decline
•behavioral changes
•seizures (possible)
the late juvenile and adult for.

Question 9

is leukodystrophy a sex-linked condition?

Accepted Answer

Sometimes: Some of the leukodystrophies, such as adrenoleukodystrophy, are sex-linked, but many others are not. Please see this web page for more information and links: http://www.Ninds.Nih.Gov/disorders/leukodystrophy/leukodystrophy.Htm.

Question 10

what happens at the end of metachromatic leukodystrophy?

Accepted Answer

Loss of function: This is a very rare disease, inherited when both parents are usually carriers. Because of the deficient enzyme, arylsulfatase a, patients suffer from a gradual destruction of  myelin sheath, the protective covering of nerves. At the end, loss of muscle function, seizures, possibly coma, and mental illness (in older people) prevail. Unfortunately, no cure, though therapies may improve life quality.

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