Question 1

can pregnant women use alteplase injections?

Accepted Answer

Contraindication: It can cause hemorrhage any where in body. It is contraindicated in pregnancy

Question 2

what is the age limit for being given tpa (alteplase)?

Accepted Answer

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation.

Question 3

what should be monitored before administering the tpa (alteplase)?

Accepted Answer

Complicated : You need to check it with your physician since it depends on many parameters , but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke,  bleeding and recent surgeries....

Question 4

could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Accepted Answer

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding.  One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began.  Another is to administer it right where it is needed, near the location of the artery which contains the clot.

Question 5

why don't stroke patients get tpa (alteplase) therapy?

Accepted Answer

Patients wait: The most common reason is they wait too long before presenting to hospital. Current guidelines for t-pa in most hospitals have been extended from 3to 4.5->5 hours after the onset of symptoms of a stroke. Part of the problem is many patients wake up with weakness/speech difficulties, the time of onset can't be determined, the patient is ineligible.Recent major surgery or bleeding are exclusions.

Question 6

who should not use alteplase injections?

Accepted Answer

Alteplase injections: CONTRAINDICATIONS:   Active internal bleeding. Recent intracranial or intraspinal surgery or serious head trauma.  Intracranial conditions that may increase the risk of bleeding.  Bleeding diathesis.  Current severe uncontrolled hypertension. Acute Ischemic Stroke • Current intracranial hemorrhage.  Subarachnoid hemorrhage. Acute Myocardial Infarction.or Pulmonary Embolism
recent stroke. See:

Question 7

how effective are alteplase injections for treating stroke?

Accepted Answer

FDA approved for AIS: AIS = acute ischemic stroke. Think FAST (http://goo.gl/I9dyo2) = Face droopy, Arms (or legs) weak, Speech difficult, Time to call 911. We have less than 3hrs after symptom onset. Check out http://www.drugs.com/cdi/alteplase.html &amp; http://www.activase.com/iscstroke (yes, I know it's Big Pharma but it's informative, and no, I have no relation).

Question 8

docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

Accepted Answer

Yes: TPA (alteplase) is not contraindicated with people taking aspirin, NSAIDs or antiplatelet drugs (dipyridamole, ticlopidine, clopidogrel).  TPA (alteplase) is a contraindicated in people on warfarin whose INR is greater than 1.7.  Use of low molecular weight heparin in the past 24 hours is also a contraindication.

Question 9

what are alteplase injections used for?

Accepted Answer

Alteplase: Alteplase is used to breakdown blood clots.

Question 10

why use alteplase drug in treatment. of myocardial infarction?

Accepted Answer

It dissolves: Blood clots.

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Doctor answers about:

Cause of alteplase allergy

A member asked:

Can pregnant women use alteplase injections?

A member asked:

What is the age limit for being given tpa (alteplase)?

A member asked:

What should be monitored before administering the tpa (alteplase)?

A member asked:

Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

A member asked:

Why don't stroke patients get tpa (alteplase) therapy?

A member asked:

Who should not use alteplase injections?

A member asked:

How effective are alteplase injections for treating stroke?

A member asked:

Docs, could a patient be given tpa (alteplase) when on antiplatelet therapy?

A member asked:

What are alteplase injections used for?

A member asked:

Why use alteplase drug in treatment. of myocardial infarction?

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