A member asked:

To reduce chances of ohss and reduce costs, can you have a mini-ivf with just clomid or letrozole + lupron shot without any other additional injections of gonadotropins?

2 doctors weighed in across 2 answers

While using just Clomid, "without gonadotropins" , ovulation may occur, but at age "40", the chances for pregnancy are very reduced, secondary to requirements for viable eggs to ovulate and be viable for fertilization. Successful pregnancy may require a more vigorous hormonal and IVF protocol.

Answered 5/18/2022

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The short answer is yes, but whether that makes sense for you will require a discussion with your doctor. You need to balance the chances of success against the risk of complications (like OHSS) in view of what you are willing to spend, and how this is done varies with each individual's circumstances and attitudes.

Answered 5/18/2022

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