A member asked:

Can depo shot cause depression?

2 doctors weighed in across 2 answers

Yes: Depo shot can worsen depression individuals who have it before. The insert has adverse effects that include possible depression **CNS Disorders and Convulsions Patients who have a history of psychic depression should be carefully observed and the drug not be readministered if the depression recurs. http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20246scs019_Depo-provera_lbl.pdf

Answered 5/4/2016

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Dr. Alan Levine answered

Specializes in Pediatrics

Yes: Depression is a known side effect of depo provera (medroxyprogesterone) and other contraceptive injections

Answered 5/4/2016

1.3k views

Thank

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