It is possible: The Depo Provera (medroxyprogesterone) injections are a hormone called progesterone. A few women who are sensitive to Progesterone and can get bloating or water retention or mood swings. So feelings of depression might be from the Depo-Provera provera. However depression and crying may have everything to do with other life issues. Speak with your doctor to help figure this out. Depression is important to treat.
Answered 10/4/2016
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