OCP and Depression: Ocp does impact moods at times as estrogen Progesterone are very strong hormone s impacting the levels of serotonin( mood chemical) a neurotransmitter responsible for mood regulation.If you are noticing severe mood disturbance please discuss with your pcp or get a psychiatric consult if there is any concerns of exacerbation of pre-existing mood issues. All the best.
Answered 9/22/2016
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