Is it normal to cry for no reason while you are on depo-provera provera (medroxyprogesterone)? sometimes i get randomly emotional

Mood changes: You can have hormonal changes while on depo-provera, especially within the first 3-4 months. As your body adapts to the hormone changes, this will improve.

Yes/no.: Depo is known to exacerbate depression in some people. If you aren't depressed but just cry, then no big deal. But if you are depressed, consider the iud... http://maybetheiud.org/ or other contraception? http://bedsider.org/methods.