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A member asked:

Please explain why does depo-provera provera (medroxyprogesterone) cause vaginal dryness?

A doctor has provided 1 answer

Low estrogen: The Depo-Provera shot lowers your estrogen level, causing vaginal dryness. The lower estrogen level also causes bone density loss, and sometimes abnormal bleeding because the uterine lining becomes thin. You could ask your doctor for an estrogen vaginal cream for the dryness.

Dr Munshower and another doctor agreed

Answered 2/19/2015

3.9k views

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Is it possible Depo-Provera provera (medroxyprogesterone) to really cause weight gain?

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