Does effexor (venlafaxine) have any effect on the endocrine system, total testosterone, or shbg?

Effexor (venlafaxine) ; endocrine: Effexor (venlafaxine) can cause sexual dysfunction, but not through direct endocrine pathways. It disinhibits the descending serotonin pathway from the brain stem through the spinal cord to neurons mediating spinal reflexes such as ejaculation and orgasm. The increased serotonin release inhibits sexual functioning. Rarely, thyroid dysfunction ; hyperprolactinemia are associated with effexor (venlafaxine).