A member asked:

I drink 1 serving of alcohol and 1 benadryl (diphenhydramine) to sleep, is this deadly?

8 doctors weighed in across 3 answers
Dr. Carlos Satulovsky answered

Specializes in Psychiatry

Risky: To mix a clearly contraindicated substance with alcohol (both causing CNS depression) is very risky. Not necessarily lethal each time you try, but to take that risk is reckless. Call 911 if you feel suicidal. Consult your dr, and please do not mix meds with alcohol. Best wishes.

Answered 6/7/2018

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Dr. Scott Bobbitt answered

Specializes in Dentistry

Best to not mix!: Alcohol and Benadryl (diphenhydramine) are both depressants to the brain. Unfortunately you can take one or the other with relative safety, but when mixed they create synergy. That is, a "1+1=3" effect, or worse if you happen to take other meds. At 63, you already know you don't heal or react the same to the things you may have taken or done as a young adult. Medications are no different--your liver/ kidneys know!

Answered 7/4/2015

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Not deadly: Do not mix drugs with alcohol, but a single serving of alcohol and benadryl is not deadly.

Answered 12/21/2020

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