Insulin resistant severe weight loss. hypoglycemic many years before diabetic.causes?

Absolute deficiency: Insulin resistance is seen in obesity or being overweight is associated with Insulin resistance state . Insulin basically enhance anabolism( versus catabolic hormones ) and utilization of glucose from all the sources ( fat , carbohydrate and , protein). Severe weight loss is an indicator of Insulin deficiency. This Insulin deficiency should be absolute as in type i or Insulin dependent diabetes.