A member asked:

Was i born with a genetic predisposition to infertility? 46xx

4 doctors weighed in across 2 answers
Dr. Khurram Rehman answered

Specializes in Fertility Medicine

46XX = normal female: 46, xx = normal female chromosome pattern. If you're 46, xx & male (very rare) you need to see a specialist. If you're a woman there is usually no identifiable genetic cause of your infertility. Fragile x syndrome is a rare cause of ovarian insufficiency/ early menopause. Some women whose mom had early menopause are increased risk of low ovarian reserve themselves. Chromosome translocations are rare.

Answered 1/10/2015

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Dr. Amr Azim answered

Specializes in Fertility Medicine

Karyotype is crude: Normal female chromosomes indicates there is no gross genetic abnormality but it is possible that a gene or more are abnormal and predispose to infertility. Unfortunately these genes are not definitely characterized yet.

Answered 12/7/2015

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