A member asked:

I took 1mg. of mirapex (pramipexole) with 300mg of neurontin for restless legs it kicked my ass it was just like being drunk, seperately no relief any suggestions?

12 doctors weighed in across 3 answers
Dr. Alan Ali answered

Specializes in Psychiatry

Neurontin (gabapentin): Additive effect of the 2 medications. Need to review with your prescribing doctor possible dose adjustments.

Answered 12/18/2013

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Dr. Alvin Lin answered

Gabapentin: Gabapentin has a well known side effect for causing sedation & making you feel drunk. That's why lowest dose is just 100mg daily. Talk to your doc about your concerns and ask about starting at lower dose. You can gradually work your way up to 3, 600mg daily total. Btw combination of Mirapex (pramipexole) & Neurontin aggravates side effects (http://goo.Gl/bpkgef).

Answered 5/16/2016

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Dr. James Marx answered

Specializes in Pain Management

Check Iron Levels: Rls frequently is a symptom of iron deficiency. Have your serum iron and ferritin levels checked and addressed when you get the results. It may require more than oral supplementation to get the level to normal..

Answered 9/26/2013

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