HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

Alprazolam and antihistamines, is this safe to take?

A doctor has provided 1 answer
Dr. Alan Ali answered

Specializes in Psychiatry

Xanax (alprazolam): I would not recommend it, due to excess sedation. If antihistamines are taken on an as needed basis, & your doctor is aware, it may be ok.

Dr Higginbotham and another doctor agreed

Answered 12/18/2013

4.9k views

Thank
Show 1 more comment

Related Questions

A member asked:

I recently have been prescribed xanax. I took 1 pill .25 at 11am. Is it safe to take a Benadryl (diphenhydramine) now at 10:04pm?? My allergies are bugging me.

6 doctors weighed in across 2 answers

A member asked:

Is it safe to take Abilify (aripiprazole) with Benadryl and xanax? It uses enzymes 2d6 & 3a4. Benadryl uses 2d6 and Xanax uses 3a4. Prescribed, of course. Curious..

A doctor has provided 1 answer

A member asked:

Is it possible for you to take Benadryl (diphenhydramine) and Xanax together?

A doctor has provided 1 answer

A member asked:

I took 1 milagram of xanax awhile ago. is it okay if I take benadryl (diphenhydramine)?

A doctor has provided 1 answer

A member asked:

I took a .25 mg Xanax about 5 hrs ago and was wondering if it's ok to take a benadryl (diphenhydramine)?

A doctor has provided 1 answer

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

After taking Xanax (alprazolam) or antihistamines or melatonin for just one night, i can't sleep at all the following night. Why?
After just one night of useing xanax, (alprazolam) antihistamines or melatonin to induce sleep, I am awake the entire night! never used to have this reaction. Why?
I took an antihistamine & forgot I did. (15 min ago) came back in room & took a Xanax bc I've had anxiety all day. Can you mix those? Should I go to t
I accidentally mixed an antihistamine with my Xanax?
I took Benadryl like at 9pm and I'm having an anxiety attack. Is it safe to take my Xanax.

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.