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A member asked:
Why does chronic glomerulonephritis lead to renal failure?
3 doctors weighed in across 2 answers
Complex: Chronic immune mediated inflammation of the glomeruli (filtering units), does them in over time and causes loss of ability to clear the daily toxin and water load.
Answered 1/18/2014
4.9k views
Scar formation: Chronic glomerulonephritis (regardless of the cause) is chronic inflammation which will lead to scar formation (aka fibrosis) in the kidneys. Fibrosis is a reperative or reactive process which turns functional elemants of the kidneys into nonfunctional fibrous tissue and hence kidney failure.
Answered 6/9/2014
4k views
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