A member asked:

Is it okay to take benadryl (diphenhydramine) with a flexeril?

A doctor has provided 1 answer

Should be ok: Benadry is an anti-allergy (anti-histamine) and Flexeril (cyclobenzaprine hcl) is essentially a serotonin anti-depressant med. But you might feel a little extra sleepy, so be careful about machinery/driving etc and try it out with some supervision the first time b/c everyone has individual reactions.

Answered 10/7/2020

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I keep getting hives! is it okay to take Benadryl (diphenhydramine) every day?

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